Decontamination is required when maintenance work, filter changes and performance tests require access to any contaminated portion of the cabinet. Decontamination may be desirable prior to certification testing when the cabinet has been used with certain BSL-2 agents and recommended when it has been used with any BSL-3 agent. Decontamination should also be performed prior to relocation of the biosafety cabinet in case a contaminated plenum is breached during its relocation.